The append() and extend() methods are both used to add items to a list in Python. However, they work slightly differently.

The append() method adds a single item to the end of a list. Here's an example:

# Define a list
my_list = [1, 2, 3]

# Use the append() method to add an item to the end of the list
my_list.append(4)

# Print the list
print(my_list)

On the other hand, the extend() method adds all the items from one list to the end of another list. Here's an example:

# Define two lists
list1 = [1, 2, 3]
list2 = [4, 5, 6]

# Use the extend() method to add the items from list2 to the end of list1
list1.extend(list2)

# Print the list
print(list1)